Issue 19, 1976
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Structures of isamic acid and methylisatoid

John Warcup Cornforth  

Abstract

Isamic acid, a red crystalline product from the reaction of isatin with ammonia, is proved to be 1,2-dihydro-2-oxospiro-[3H-indole-3,2′(1′H)-quinazoline]-4′-carboxylic acid, as suggested by G. F. Field. The colour and lack of basicity appear to be due in part to spiroconjugation. Methylisatoid, from O-methylisatin and moist air or aqueous acetic acid, is shown by rational synthesis and degradation to be methyl 6,12-dihydro-12-hydroxy-6-oxoindolo-[2,1-b]quinazoline-12-carboxylate.

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Article information

DOI
https://doi.org/10.1039/P19760002004
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1976, 2004-2009

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Structures of isamic acid and methylisatoid

J. W. Cornforth, J. Chem. Soc., Perkin Trans. 1, 1976, 2004 DOI: 10.1039/P19760002004

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