Issue 0, 1973
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

The structure and absolute configuration of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system

William Dalziel,   Barrie Hesp,   Karen M. Stevenson  and  John A. J. Jarvis  

Abstract

The structure and absolute configuration of the novel tetracyclic diterpenoid aphidicolin, an antimitotic and antiviral metabolite of Cephalosporium aphidicola Petch, have been determined, and a systematic nomenclature is proposed. Possible biosynthetic routes to aphidicolin are discussed. Derivatives of aphidicolin, including possible biogenetic precursors and the C(3)- and C(16)-epimers of the antibiotic have been prepared. The high resolution i.r. hydroxyfrequencies are reported for a number of ring-A 1,3-diols derived from aphidicolin.

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Article information

DOI
https://doi.org/10.1039/P19730002841
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1973, 2841-2851

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The structure and absolute configuration of the antibiotic aphidicolin: a tetracyclic diterpenoid containing a new ring system

W. Dalziel, B. Hesp, K. M. Stevenson and J. A. J. Jarvis, J. Chem. Soc., Perkin Trans. 1, 1973, 2841 DOI: 10.1039/P19730002841

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