Issue 29, 2021

Tantalum(v) peroxido complexes as phosphatase inhibitors: a comparative study vis-a-vis peroxidovanadates

Abstract

The present work illustrates the synthesis and comprehensive characterization of novel peroxidotantalum(V) complexes anchored to water soluble polymer (WSP) matrices viz., [Ta2(O2)6(carboxylate)2]–PA [PA = poly(sodium acrylate)] (PATa) and [Ta(O2)3(sulfonate)2]–PSS [PSS = poly(sodium 4-styrene sulfonate)] (PSSTa) and their identification as potent inhibitors of acid phosphatase (ACP) activity. Using a set comprising tantalum(V) and vanadium(V) peroxides in similar macro ligand environments, and wheat thylakoid acid phosphatase as a model enzyme, it has been demonstrated for the first time that peroxidotantalum (pTa) derivatives are 2–3 fold more active as ACP inhibitors (IC50: 0.34 μM for PSSTa) compared to their V containing analogues (IC50: 1.22 μM). Enzyme kinetics analysis further revealed that the pTa and peroxidovanadate (pV) compounds tested, irrespective of the nature of their ligand environment, inhibit ACP function exclusively via a non-competitive pathway with Ki and Kii values ranging between 0.2 and 4.7 μM. Importantly, under the effect of the enzyme catalase, the pTa compounds with a rate of peroxide loss as low as 0.92 μM min−1 (PATa) emerged to be remarkably more resistant to degradation relative to the corresponding pV compound, which degraded at a significantly faster rate (5.80 μM min−1).

Graphical abstract: Tantalum(v) peroxido complexes as phosphatase inhibitors: a comparative study vis-a-vis peroxidovanadates

Supplementary files

Article information

Article type
Paper
Submitted
28 Feb 2021
Accepted
03 Jun 2021
First published
11 Jun 2021

New J. Chem., 2021,45, 12848-12862

Tantalum(V) peroxido complexes as phosphatase inhibitors: a comparative study vis-a-vis peroxidovanadates

G. Saikia, H. Talukdar, K. Ahmed, N. K. Gour and N. S. Islam, New J. Chem., 2021, 45, 12848 DOI: 10.1039/D1NJ01005K

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