Issue 4, 2019
From the journal:

Green Chemistry

Three-component 3-(phosphoryl)methylindole synthesis from indoles, H-phosphine oxides and carbonyl compounds under metal-free conditions†

Jiaoting Pan,a   Runmin Zhao,b   Jiami Guo,b   Dumei Ma,b   Ying Xia,a   Yuxing Gao, ORCID logo *a   Pengxiang Xu*a  and  Yufen Zhao ORCID logo a  

* Corresponding authors

a Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China
E-mail: gaoxingchem@xmu.edu.cn, xpengxiang@xmu.edu.cn

b Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, China

Abstract

The first facile and efficient acid-catalyzed three-component reaction of indoles, H-phosphine oxides and carbonyl compounds has been developed, providing a general, one-pot approach to structurally diverse C3-alkylated indole derivatives accompanied by concurrent C–P/C–C bond formation with remarkable functional group tolerance and excellent regioselectivity.

Graphical abstract: Three-component 3-(phosphoryl)methylindole synthesis from indoles, H-phosphine oxides and carbonyl compounds under metal-free conditions

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Article information

DOI
https://doi.org/10.1039/C8GC03530J
Article type
Communication
Submitted
11 Nov 2018
Accepted
19 Jan 2019
First published
22 Jan 2019

Green Chem., 2019,21, 792-797

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Three-component 3-(phosphoryl)methylindole synthesis from indoles, H-phosphine oxides and carbonyl compounds under metal-free conditions

J. Pan, R. Zhao, J. Guo, D. Ma, Y. Xia, Y. Gao, P. Xu and Y. Zhao, Green Chem., 2019, 21, 792 DOI: 10.1039/C8GC03530J

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