Concentrations dominated membrane permeability variation by fullerol nanoparticles on a single living HeLa cell

Naiyun Liu; Mumei Han; Yalin Zhang; Xiuqin Wu; Juan Liu; Hao Li; Tiantian Cao; Xueyan Nan; Hui Huang; Yang Liu; Ning Chen; Chunru Wang; Zhenhui Kang

doi:10.1039/C6TB01474G

Concentrations dominated membrane permeability variation by fullerol nanoparticles on a single living HeLa cell†

Naiyun Liu,^a Mumei Han,^a Yalin Zhang,^a Xiuqin Wu,^a Juan Liu,^a Hao Li,^a Tiantian Cao,^b Xueyan Nan,^a Hui Huang,*^a Yang Liu,*^a Ning Chen,^b Chunru Wang^c and Zhenhui Kang*^a

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* Corresponding authors

^a Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu, China
E-mail: zhkang@suda.edu.cn, yangl@suda.edu.cn

^b Laboratory of Advanced Optoelectronic Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, Jiangsu 215123, China

^c Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

Abstract

The effects in HeLa cell membrane permeability caused by the fullerenols C₆₀(OH)_n with different concentrations were studied by scanning electrochemical microscopy (SECM). We demonstrate that C₆₀(OH)_n has very low cytotoxicity, although it can still have strong effects on the cell membrane permeability. In the presence of 1 × 10⁻³ mg mL⁻¹ (1 ppm) C₆₀(OH)_n, the cell membrane permeability increases by 26% after 76 min, which is reversible. When C₆₀(OH)_n concentration is over 25 × 10⁻³ mg mL⁻¹ (25 ppm), the change in membrane permeability (increased 19%) is irreversible.

Journal of Materials Chemistry B

Concentrations dominated membrane permeability variation by fullerol nanoparticles on a single living HeLa cell†

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Concentrations dominated membrane permeability variation by fullerol nanoparticles on a single living HeLa cell

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