A pH-responsive poly(ether amine) micelle with hollow structure for controllable drug release
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Abstract
An effective strategy was developed to fabricate pH-responsive poly(ether amine) hollow nanoparticles for the controllable loading and release of anticancer drugs. The amphiphilic poly(ether amine) containing coumarin groups (gPEAC) was first synthesized, which was further modified with myristic acid to form comb-like poly(ether amine) (acPEAC). The nanoscale micelles formed by acPEAC in aqueous solution were cross-linked through the photo-dimerization of coumarin groups. Then hollow micelles were obtained by removing their hydrophobic cores of myristic ester. The anticancer drug doxorubicin (DOX) was directly loaded into the micelles without any organic solvent. The DOX-loaded micelles displayed desirable pH-sensitive release behaviours. Moreover, the hollow micelles exhibit great potential for loading drugs and controllable release, and drug-loaded micelles indicate comparable anticancer efficacy as free DOX. This work highlights the potential for the rational design of functional polymers as smart drug carriers.
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