Issue 67, 2016, Issue in Progress

Supramolecular hydrogel of non-steroidal anti-inflammatory drugs: preparation, characterization and ocular biocompatibility

Abstract

A supramolecular hydrogel based on a peptide (GFFY) and non-steroidal anti-inflammatory drugs (naproxen and ibuprofen) was synthesized for use as a topical gel. Using a heating–cooling strategy, the drug–peptide derivatives could self-assemble into nanofibers in aqueous solution to produce a supramolecular hydrogel. The different drug molecules used as the capping group had a profound effect on the self-assembly behaviour measured by circular dichroism. The supramolecular hydrogels were confirmed by rheological measurements to be thixotropic and had no apparent toxicity in vitro against HCEC and L-929 cells after 24 h incubation. More importantly, an in vivo ocular biocompatibility test indicated that the supramolecular hydrogels were well tolerated in rabbits and had satisfactory ocular biocompatibility, suggesting that they are promising candidates for the delivery of ocular drugs.

Graphical abstract: Supramolecular hydrogel of non-steroidal anti-inflammatory drugs: preparation, characterization and ocular biocompatibility

Supplementary files

Article information

Article type
Paper
Submitted
13 Apr 2016
Accepted
12 Jun 2016
First published
13 Jun 2016

RSC Adv., 2016,6, 62434-62438

Supramolecular hydrogel of non-steroidal anti-inflammatory drugs: preparation, characterization and ocular biocompatibility

X. Li, G. Pu, X. Yu, S. Shi, J. Yu, W. Zhao, Z. Luo, Z. He and H. Chen, RSC Adv., 2016, 6, 62434 DOI: 10.1039/C6RA09615H

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