Issue 64, 2016, Issue in Progress

Preparation of chitosan nanoparticles by nanoprecipitation and their ability as a drug nanocarrier

Abstract

Polysaccharide-based nanoparticles represent a very promising drug delivery platform, particularly for the transmucosal delivery of bioactive macromolecules. Thus, the aim of this paper is to revisit the nanoprecipitation processes for preparing chitosan nanoparticles and to evaluate the influence of the process parameters on their characteristics. Chitosan was dissolved in water as N-(methylsulfonic acid) chitosan or directly in aqueous acetic acid. Methanol was used as the nonsolvent diffusing phase. Nanoparticles became smaller as the polymer concentration decreased or the nonsolvent to solvent volume ratio increased. Particles prepared in acidic media are slightly larger than those precipitated from N-(methylsulfonic acid) chitosan. Replacement of methanol by water in the suspension medium resulted in a notorious increase in their size. On the other hand, very little additions of Tween-80 to the nonsolvent phase render smaller nanoparticles, with a similar mean-size values. Nanoparticles precipitated in methanol have roughly the same dimensions, regardless of the ionic strength of the chitosan solution. These chitosan nanoparticles have good association and loading efficiency values of a model substance showing their ability as a nanocarrier for drug delivery systems.

Graphical abstract: Preparation of chitosan nanoparticles by nanoprecipitation and their ability as a drug nanocarrier

Article information

Article type
Paper
Submitted
11 Mar 2016
Accepted
14 Jun 2016
First published
15 Jun 2016

RSC Adv., 2016,6, 59250-59256

Preparation of chitosan nanoparticles by nanoprecipitation and their ability as a drug nanocarrier

A. G. Luque-Alcaraz, J. Lizardi-Mendoza, F. M. Goycoolea, I. Higuera-Ciapara and W. Argüelles-Monal, RSC Adv., 2016, 6, 59250 DOI: 10.1039/C6RA06563E

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