Issue 56, 2016, Issue in Progress
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RSC Advances

Gadolinium/DOTA functionalized poly(ethylene glycol)-block-poly(acrylamide-co-acrylonitrile) micelles with synergistically enhanced cellular uptake for cancer theranostics†

Guoquan Tong,ac   Zhuangnian Fang,b   Gang Huang,ad   Yihan Jing, ORCID logo ac   Shulin Dai,ac   Qing Jiang,ac   Chao Zhang,*ac   Shi-Ting Feng*b  and  Zi-Ping Li*b  

* Corresponding authors

a School of Engineering, Sun Yat-sen University, Guangzhou 510006, P. R. China
E-mail: zhchao9@mail.sysu.edu.cn
Fax: +86-20-39332312
Tel: +86-20-39332145

b Department of Radiology, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou, Guangdong 510080, China
E-mail: fst1977@163.com, liziping163@163.com
Tel: +86-20-87332200-8466

c Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, Sun Yat-sen University, Guangzhou, Guangdong 510006, China

d Guangxi Bioscience and Technology Research Center and National Engineering Research Center for Non-food Biorefinery, Guangxi Academy of Sciences, Nanning, Guangxi 530007, China

Abstract

The combination of diagnostic and therapeutic functions into a nano-carrier could achieve a delivery system with both accurate diagnosis and delivery capabilities. Herein, a functionalized polymer of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-poly(ethyleneglycol)-block-poly(acrylamide-co-acrylonitrile) (DOTA-PEG-b-poly(AAm-co-AN)) was designed and synthesized. Doxorubicin (DOX) and gadolinium ions (Gd3+) were loaded into the hydrophobic core and chelated on the shell of the micelles during the self-assembling process to endow the prepared micelles with drug delivery and magnetic resonance imaging functionalities. Such theranostics micelles exhibited noticeable accelerated DOX release with elevated temperature and high proton relaxivity r1 (25.88 mM−1 s−1). Moreover, the Gd3+/DOX loaded micelle presented a synergistically enhanced cellular uptake efficiency (2.12 times that of free DOX) as compared with free drug or that loaded in micelles without Gd3+. The micelles provide promising application for chemotherapy and simultaneous enhanced magnetic resonance imaging (MRI) of cancer.

Graphical abstract: Gadolinium/DOTA functionalized poly(ethylene glycol)-block-poly(acrylamide-co-acrylonitrile) micelles with synergistically enhanced cellular uptake for cancer theranostics

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Article information

DOI
https://doi.org/10.1039/C6RA04038A
Article type
Paper
Submitted
14 Feb 2016
Accepted
17 May 2016
First published
18 May 2016

RSC Adv., 2016,6, 50534-50542

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Gadolinium/DOTA functionalized poly(ethylene glycol)-block-poly(acrylamide-co-acrylonitrile) micelles with synergistically enhanced cellular uptake for cancer theranostics

G. Tong, Z. Fang, G. Huang, Y. Jing, S. Dai, Q. Jiang, C. Zhang, S. Feng and Z. Li, RSC Adv., 2016, 6, 50534 DOI: 10.1039/C6RA04038A

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