Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T1-weighted MRI

Yuan-Peng Rui; Bo Liang; Fenglin Hu; Jie Xu; Yi-Feng Peng; Pei-Hao Yin; Yourong Duan; Chunfu Zhang; Hongchen Gu

doi:10.1039/C6RA00347H

Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T₁-weighted MRI†

Yuan-Peng Rui,‡^a Bo Liang,‡^ab Fenglin Hu,‡^c Jie Xu,^a Yi-Feng Peng,^a Pei-Hao Yin,*^a Yourong Duan,*^cd Chunfu Zhang*^ce and Hongchen Gu^c

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* Corresponding authors

^a Department of Radiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200062, China
E-mail: yinpeihao1975@hotmail.com

^b Department of Oncology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang Province, China

^c State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200030, China
E-mail: yrduan@shsci.org; cfzhang@sjtu.edu.cn

^d State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, China

^e Department of Nuclear Medicine, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China

Abstract

Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles with high stability in physiological conditions have great potential for T₁-weighted MRI. In the current study, we developed a procedure for ultra-large-scale production of USPIOs (1.5 kg per batch) for T₁-weighted MRI. The USPIOs were coated with poly(acrylic acid) (PAA@USPIOs). They were uniform in size (∼4.5 nm) and very stable in physiological conditions even after being sterilized in an autoclave. Due to their small size, the PAA@USPIOs demonstrated good T₁ MRI contrast effect and could be used for both first-pass and steady-state magnetic resonance angiography (MRA). After being injected with PAA@USPIOs at the dose of 135 μmol Fe per kg, the head–neck vasculatures and abdominal artery of rabbits and the coronary artery of pigs could be clearly visualized by T₁-weighted MRI. Moreover, PAA@USPIOs were highly tolerable by animals. Our study indicated that the procedure developed in this study has great promise for large-scale production of USPIOs for T₁-weighted MRI for future clinical applications.

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Article information

DOI: https://doi.org/10.1039/C6RA00347H
Article type: Paper
Submitted: 06 Jan 2016
Accepted: 18 Feb 2016
First published: 22 Feb 2016

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RSC Adv., 2016,6, 22575-22585

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Ultra-large-scale production of ultrasmall superparamagnetic iron oxide nanoparticles for T₁-weighted MRI

Y. Rui, B. Liang, F. Hu, J. Xu, Y. Peng, P. Yin, Y. Duan, C. Zhang and H. Gu, RSC Adv., 2016, 6, 22575 DOI: 10.1039/C6RA00347H

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