Issue 121, 2015

A greener procedure for the synthesis of α-ureidophosphonates under ultrasound irradiation. An X-ray crystallographic study

Abstract

An efficient, eco-sustainable and greener procedure for the synthesis of α-ureidophosphonates via a one-pot three-component reaction of aldehydes, urea/thiourea and triethylphosphite or diethylphosphite using ultrasonic irradiation under solvent- and catalyst-free conditions at 75°, is developed. The desired products were obtained in excellent yields within short reaction times (15–30 min). Crystals of diethyl[α-ureido-(4-methylphenyl)]methyl phosphonate suitable for X-ray study have been obtained after recrystallization in a mixture of diethyl ether and n-hexane. The detailed analysis of the molecular and crystal structure is presented.

Graphical abstract: A greener procedure for the synthesis of α-ureidophosphonates under ultrasound irradiation. An X-ray crystallographic study

Supplementary files

Article information

Article type
Paper
Submitted
25 Sep 2015
Accepted
13 Nov 2015
First published
13 Nov 2015

RSC Adv., 2015,5, 99775-99780

Author version available

A greener procedure for the synthesis of α-ureidophosphonates under ultrasound irradiation. An X-ray crystallographic study

A. Bouzina, M. Berredjem, S. Bouacida, H. Merazig and N. Aouf, RSC Adv., 2015, 5, 99775 DOI: 10.1039/C5RA19886K

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