Regio- and stereoselective synthesis of ensulfonamides/enamides via catalyst-free intermolecular addition of indoles/pyrroles/imidazole to allenamides†
Abstract
A catalyst-free intermolecular addition of indoles, pyrroles, and imidazole to allenamides is reported. The reaction proceeds smoothly at 80 °C and provides a series of (E)-ensulfonamide derivatives in high yields with excellent regioselectivity. Two enamides 3k and 3l can also obtained when using acyl in place of tosyl as an amino-protecting group of allenamides.
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