Issue 78, 2015
From the journal:

RSC Advances

Total synthesis of (+)-petromyroxol via tandem α-aminoxylation–allylation and asymmetric dihydroxylation–SN2 cyclization approach†‡

U. Nookarajua  and  Pradeep Kumar*a  

* Corresponding authors

a CSIR-National Chemical Laboratory, Division of Organic Chemistry, Dr Homi Bhabha Road, Pune, India
E-mail: pk.tripathi@ncl.res.in
Fax: +91 20 25902629
Tel: +91 20 25902760

Abstract

The total synthesis of (+)-petromyroxol, a tetrahydrofuran (THF)-diol fatty acid, isolated from sea lamprey larvae (Petromyzon marinus) is reported. The present synthesis employs a tandem α-aminoxylationallylation, cross metathesis and tandem asymmetric dihydroxylation–SN2 cyclization as key steps.

Graphical abstract: Total synthesis of (+)-petromyroxol via tandem α-aminoxylation–allylation and asymmetric dihydroxylation–SN2 cyclization approach

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Article information

DOI
https://doi.org/10.1039/C5RA10405J
Article type
Communication
Submitted
02 Jun 2015
Accepted
17 Jul 2015
First published
17 Jul 2015

RSC Adv., 2015,5, 63311-63317

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Total synthesis of (+)-petromyroxol via tandem α-aminoxylation–allylation and asymmetric dihydroxylation–SN2 cyclization approach

U. Nookaraju and P. Kumar, RSC Adv., 2015, 5, 63311 DOI: 10.1039/C5RA10405J

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