Issue 40, 2015
From the journal:

RSC Advances

Biodegradable multi-liposomal containers†

Alexander A. Yaroslavov,*a   Anna A. Efimova,a   Andrey V. Sybachin,a   Sergey N. Chvalun,b   Alevtina I. Kulebyakinab  and  Ekaterina V. Kozlovab  

* Corresponding authors

a Lomonosov Moscow State University, 119991, Leninskie Gory, 1-3, Moscow, Russia
E-mail: yaroslav@genebee.msu.ru
Fax: +74959390174
Tel: +74959393116

b National Research Centre “Kurchatov Institute”, 123182, Akademika Kurchatova sq., 1, Moscow, Russia
E-mail: presscentr@kiae.ru
Fax: +74991967038
Tel: +74991967038

Abstract

Here we describe biodegradable multi-liposomal core–shell containers. They are made of a poly-L-lactide–polyethyleneoxyde–poly-L-lactide triblock-copolymer core covered by electrostatically adsorbed liposomes. The liposomes retain their integrity after adsorption, which allows them to be used for encapsulating bioactive compounds. The multi-liposomal containers eventually decompose, by being attacked by hydrolytic enzymes, which makes them promising for use in drug delivery.

Graphical abstract: Biodegradable multi-liposomal containers

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Article information

DOI
https://doi.org/10.1039/C5RA00835B
Article type
Paper
Submitted
14 Jan 2015
Accepted
18 Mar 2015
First published
18 Mar 2015

RSC Adv., 2015,5, 31460-31464

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Biodegradable multi-liposomal containers

A. A. Yaroslavov, A. A. Efimova, A. V. Sybachin, S. N. Chvalun, A. I. Kulebyakina and E. V. Kozlova, RSC Adv., 2015, 5, 31460 DOI: 10.1039/C5RA00835B

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