Issue 21, 2014
From the journal:

Journal of Materials Chemistry B

Light and reductive dual stimuli-responsive PEI nanoparticles: “AND” logic response and controllable release

Qi Huang,†a   Tao Liu,†a   Chunyan Bao,a   Qiuning Lin,a   Meixin Maa  and  Linyong Zhu*a  

* Corresponding authors

a Key Laboratory for Advanced Materials, Institute of Fine Chemicals, East China University of Science and Technology, 130# Meilong Road, Shanghai, P. R. China
E-mail: linyongzhu@ecust.edu.cn
Fax: +86-21-64253742

Abstract

“AND” logic responsive polyetherimide (PEI)-based polymers PENS were constituted by attaching the photoresponsive o-nitrobenzyl phototrigger and reductive responsive disulfide linker to the polymer PEI. This dual-responsive system maintained micelle-like assembly upon single photo or reductive stimuli. The disassembly only occurred when photo and reductive signals were input at the same time. This smart system was therefore applied as a carrier for the controlled release of the anti-cancer drug doxorubicin (DOX), which exhibited effective release only when UV irradiation and GSH reduction were applied simultaneously.

Graphical abstract: Light and reductive dual stimuli-responsive PEI nanoparticles: “AND” logic response and controllable release

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Article information

DOI
https://doi.org/10.1039/C4TB00087K
Article type
Paper
Submitted
14 Jan 2014
Accepted
20 Feb 2014
First published
24 Feb 2014

J. Mater. Chem. B, 2014,2, 3333-3339

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Light and reductive dual stimuli-responsive PEI nanoparticles: “AND” logic response and controllable release

Q. Huang, T. Liu, C. Bao, Q. Lin, M. Ma and L. Zhu, J. Mater. Chem. B, 2014, 2, 3333 DOI: 10.1039/C4TB00087K

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