Issue 6, 2015
From the journal:

RSC Advances

Oxidation- and thermo-responsive poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogels cross-linked via diselenides for controlled drug delivery†

Xinfeng Cheng,ab   Yong Jin,*cd   Tongbing Sun,ab   Rui Qi,ab   Baozhu Fanab  and  Hanping Licd  

* Corresponding authors

a Chengdu Institute of Organic Chemistry, Chinese Academy of Science, Center of Polymer Science and Technology, Chengdu 610041, People's Republic of China

b University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, People's Republic of China

c National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University, Chengdu 610065, People's Republic of China
E-mail: jinyong@cioc.ac.cn
Tel: +86-28-85214963

d Key Laboratory of Leather Chemistry and Engineering (Sichuan University), Ministry of Education, Chengdu 610065, People's Republic of China

Abstract

A novel diselenide crosslinked poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogel was successfully synthesized and characterized. The resultant hydrogel showed a swelling–shrinkage behavior as a function of external temperature because of the unique hydrophilic–hydrophobic transition of poly(N-isopropylacrylamide) (PNIPAM) segments. In addition to the temperature-dependent response, the oxidation-induced gel-to-sol transition of the hydrogel was also observed. The salicylic acid (SA) loaded hydrogels were prepared in order to investigate their stimuli-responsive release behaviors. The cumulative release profile of the SA-loaded hydrogels showed a thermo-induced slow sustained drug release and an oxidation-induced quick burst release, exhibiting temperature/oxidation dual-stimuli-responsive drug release. This novel type of hydrogels may hold great promise for controlled drug delivery systems.

Graphical abstract: Oxidation- and thermo-responsive poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogels cross-linked via diselenides for controlled drug delivery

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Article information

DOI
https://doi.org/10.1039/C4RA13500H
Article type
Paper
Submitted
30 Oct 2014
Accepted
03 Dec 2014
First published
05 Dec 2014

RSC Adv., 2015,5, 4162-4170

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Oxidation- and thermo-responsive poly(N-isopropylacrylamide-co-2-hydroxyethyl acrylate) hydrogels cross-linked via diselenides for controlled drug delivery

X. Cheng, Y. Jin, T. Sun, R. Qi, B. Fan and H. Li, RSC Adv., 2015, 5, 4162 DOI: 10.1039/C4RA13500H

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