Issue 88, 2014
From the journal:

RSC Advances

meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity†

Thumuganti Gayathri,‡ac   Ayan Kumar Barui,‡bc   Suthari Prashanthi,a   Chitta Ranjan Patra*b  and  Surya Prakash Singh*a  

* Corresponding authors

a Inorganic and Physical Chemistry Division, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad-500007, India
E-mail: spsingh@iict.res.in
Fax: +91-40-271609
Tel: +91-40-27191480

b Biomaterials Group, CSIR-Indian Institute of Chemical Technology, Uppal Road, Tarnaka, Hyderabad-500007, India
E-mail: crpatra@iict.res.in

c Academy of Scientific & Innovative Research (AcSIR), 2 Rafi Marg, New Delhi, India

Abstract

A series of meso-substituted thienyl BODIPY analogues (1, 1a–g) have been designed and synthesized. Among those, compounds 1c, 1d and 1e show biocompatibility towards endothelial cells whereas 1c and 1d show significant cytotoxicity towards cancerous cells. The formation of intracellular reactive oxygen species (ROS) and the activation of the apoptotic protein may be a plausible mechanism for the anti-proliferative nature of 1c and 1d. Additionally, compounds 1c, 1d, and 1e fluoresce inside the cancer cells. The combined results suggest the future theranostic (therapeutics + diagnostics) applications of 1c and 1d in cancer diseases.

Graphical abstract: meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity

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Article information

DOI
https://doi.org/10.1039/C4RA07424F
Article type
Communication
Submitted
22 Jul 2014
Accepted
15 Sep 2014
First published
15 Sep 2014

RSC Adv., 2014,4, 47409-47413

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meso-Substituted BODIPY fluorescent probes for cellular bio-imaging and anticancer activity

T. Gayathri, A. K. Barui, S. Prashanthi, C. R. Patra and S. P. Singh, RSC Adv., 2014, 4, 47409 DOI: 10.1039/C4RA07424F

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