Issue 30, 2014

Cucurbituril/hydroxyapatite based nanoparticles for potential use in theranostic applications

Abstract

We present the engineering of cucurbituril/hydroxyapatite based theranostic nanoparticles with a high aspect ratio and a needle shaped morphology. These particles with varying sizes, surface charges and tunable degradation profiles manifested the advantages of the presence of cucurbituril with respect to drug loading, encapsulation efficacy and release kinetics. In vitro release profiles with two model drugs, Doxorubicin hydrochloride (Dox, hydrophilic) and Nile Red dye (NR, hydrophobic), were evaluated. It was ascertained that hydrophilic Dox was released at a faster rate compared to hydrophobic NR over similar time periods. The concomitant presence of samarium (Sm3+) and CB[7] confers theranostic potential to the synthesized nanoparticles. Cellular toxicity effects systematically assessed using MTT and live/dead assay protocols indicate inappreciable toxicity. The nanoparticles further reveal excellent blood compatibility and cellular internalization properties as visualized by fluorescence microscopy. Particles excited at 300 nm revealed Dox emission in the green channel (470 nm) as well as Sm3+ emission in the red channel (590 nm). These studies unravel the potential of these nanoparticles for effective theranostic applications.

Graphical abstract: Cucurbituril/hydroxyapatite based nanoparticles for potential use in theranostic applications

Supplementary files

Article information

Article type
Paper
Submitted
11 Apr 2014
Accepted
28 May 2014
First published
29 May 2014

CrystEngComm, 2014,16, 6929-6936

Author version available

Cucurbituril/hydroxyapatite based nanoparticles for potential use in theranostic applications

S. P. Victor, W. Paul, M. Jayabalan and C. P. Sharma, CrystEngComm, 2014, 16, 6929 DOI: 10.1039/C4CE00766B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements