Issue 23, 2013
From the journal:

Journal of Materials Chemistry B

Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy†

Da-Wei Wang,‡ah   Xiao-Ming Zhu,‡b   Siu-Fung Lee,a   Ho-Man Chan,c   Hung-Wing Li,c   Siu Kai Kong,d   Jimmy C. Yu,a   Christopher H. K. Cheng,*e   Yi-Xiang J. Wang*b  and  Ken Cham-Fai Leung*acfg  

* Corresponding authors

a Department of Chemistry, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P. R. China

b Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P. R. China
E-mail: yixiang_wang@cuhk.edu.hk
Tel: +852 2632 2289

c Department of Chemistry, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China

d School of Life Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P. R. China

e School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, NT, Hong Kong SAR, P. R. China
E-mail: chkcheng@cuhk.edu.hk
Tel: +852 3943 6801

f Institute of Creativity, The Hong Kong Baptist University, Kowloon Tong, Kowloon, Hong Kong SAR, P. R. China
E-mail: cfleung@hkbu.edu.hk
Fax: +852 3411 7348
Tel: +852 3411 2319

g Institute of Molecular Functional Materials, University Grants Committee, Hong Kong SAR, P. R. China

h State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Abstract

In this paper, we investigated the functional imaging and targeted therapeutic properties of core@multi-shell nanoparticles composed of a superparamagnetic iron oxide (SPIO) core and gold nanorods (GNRs) in the mesoporous silica shells functionalized with folic acid (Fe3O4@SiO2@GNRs@mSiO2–FA). The as-synthesized five-component hybrid nanocomposite was revealed to have insignificant cytotoxicity. Intracellular uptake of the nanoparticles was studied in the folate receptor over-expressing human epidermoid carcinoma of the nasopharynx (KB) cells. Due to their magnetic/optical properties as well as the folate targeting potential, compared with Fe3O4@SiO2@GNRs@mSiO2 nanoparticles, higher cellular uptake efficiency was observed for Fe3O4@SiO2@GNRs@mSiO2–FA nanoparticles in KB cells. Characterizations were achieved using both dark field and magnetic resonance (MR) imaging techniques. The hyperthermia induced by Fe3O4@SiO2@GNRs@mSiO2–FA nanoparticles resulted in a higher cytotoxicity in KB cells. Thus, the Fe3O4@SiO2@GNRs@mSiO2–FA hybrid nanomaterial is an effective and promising MR imaging and photothermal therapy agent for folate-receptor over-expressing cancer cells.

Graphical abstract: Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy

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Article information

DOI
https://doi.org/10.1039/C3TB20090F
Article type
Paper
Submitted
22 Jan 2013
Accepted
11 Apr 2013
First published
11 Apr 2013

J. Mater. Chem. B, 2013,1, 2934-2942

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Folate-conjugated Fe3O4@SiO2@gold nanorods@mesoporous SiO2 hybrid nanomaterial: a theranostic agent for magnetic resonance imaging and photothermal therapy

D. Wang, X. Zhu, S. Lee, H. Chan, H. Li, S. K. Kong, J. C. Yu, C. H. K. Cheng, Y. J. Wang and K. C. Leung, J. Mater. Chem. B, 2013, 1, 2934 DOI: 10.1039/C3TB20090F

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