Issue 11, 2013
From the journal:

Journal of Materials Chemistry B

Self-assembly of polyion complex nanocarriers from ammonium glycyrrhizinate and monomethoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone)

Yan Zhang,*a   Jianjing Liu,a   Yutong Fu,a   Ke Tan,b   Zhaoyang Yeb  and  Meidong Lang*a  

* Corresponding authors

a Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: zhang_yan@ecust.edu.cn, mdlang@ecust.edu.cn
Fax: +86-21-64251764
Tel: +86-21-64251764

b State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, Shanghai, China

Abstract

A novel polyion complex (PIC) drug carrier was developed via electrostatic self-assembly in aqueous media based on our previous copolymer methoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone) (mPEG-b-PACL) and anti-hepatotoxic drug ammonium glycyrrhizinate (AMG). The formation and the physicochemical properties of the polyion complex nanoparticles in aqueous solution were investigated by various methods. The results demonstrated that AMG was encapsulated successfully and the nanoparticles had a core–shell or tri-layer spherical structure based on the length of the PACL. The AMG/PACL PIC also displayed a high loading capacity and encapsulation efficiency of up to 41.8% and 91.7%, respectively. Furthermore, the nanoparticles enabled a continuous and sustained in vitro AMG release and the release half time was about 3 times that of the free AMG's. Results obtained by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, flow cytometry and fluorescence microscopy revealed that AMG loaded nanoparticles demonstrated greater prevention of liver cell apoptosis induced by lipopolysaccharide (LPS). These findings indicated that methoxy poly(ethylene glycol) (mPEG)-b-poly(γ-amino-ε-caprolactone) could be an efficient AMG carrier and could even be used as a delivery template for some other negatively charged water-soluble drugs or gene delivery systems.

Graphical abstract: Self-assembly of polyion complex nanocarriers from ammonium glycyrrhizinate and monomethoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone)

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C3TB00012E
Article type
Paper
Submitted
29 Oct 2012
Accepted
14 Jan 2013
First published
14 Jan 2013

J. Mater. Chem. B, 2013,1, 1614-1621

Permissions

Request permissions

Self-assembly of polyion complex nanocarriers from ammonium glycyrrhizinate and monomethoxy poly(ethylene glycol)-b-poly(γ-amino-ε-caprolactone)

Y. Zhang, J. Liu, Y. Fu, K. Tan, Z. Ye and M. Lang, J. Mater. Chem. B, 2013, 1, 1614 DOI: 10.1039/C3TB00012E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements