Issue 20, 2014
From the journal:

RSC Advances

Synthesis of porous iron oxide microspheres by a double hydrophilic block copolymer†

B. P. Bastakoti,a   Hiroaki Sukegawa,a   Kevin C.-W. Wu*b  and  Yusuke Yamauchi*a  

* Corresponding authors

a National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
E-mail: Yamauchi.Yusuke@nims.go.jp

b Department of Chemical Engineering, National Taiwan University, No. 1, Sec. 4, Roosevelt Road, Taipei 10617, Taiwan
E-mail: kevinwu@ntu.edu.tw
Fax: +886 2 2362 3040
Tel: +886 2 3366 3064

Abstract

Porous microspheres of iron oxide (Fe2O3) are synthesized using a double hydrophilic block copolymer of poly(ethylene oxide)-block-poly(acrylic acid) (PEO-b-PAA). The PAA block with negative charge strongly interacts with ferric ions. The assembly of primary nanoparticles at elevated temperature forms the porous microsphere of Fe2O3. The MTT assay of the microspheres based on HepG2 cell indicates good biocompatibility. The thorough porosity of microspheres can accommodate a large amount of anticancer drug cisplatin.

Graphical abstract: Synthesis of porous iron oxide microspheres by a double hydrophilic block copolymer

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Article information

DOI
https://doi.org/10.1039/C3RA47490A
Article type
Communication
Submitted
10 Dec 2013
Accepted
13 Jan 2014
First published
14 Jan 2014

RSC Adv., 2014,4, 9986-9989

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Synthesis of porous iron oxide microspheres by a double hydrophilic block copolymer

B. P. Bastakoti, H. Sukegawa, K. C.-W. Wu and Y. Yamauchi, RSC Adv., 2014, 4, 9986 DOI: 10.1039/C3RA47490A

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