Issue 10, 2013
From the journal:

New Journal of Chemistry

Visualizing the changes in the cellular redox environment using a novel profluorescent rhodamine nitroxide probe†

Linying Cao,ab   Qingfeng Wu,c   Qiang Li,c   Shijun Shaoa  and  Yong Guo*a  

* Corresponding authors

a Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, P. R. China
E-mail: guoyong@licp.cas.cn
Fax: +86-931-8277088
Tel: +86 931 4968274

b University of Chinese Academy of Sciences, Beijing 100039, P. R. China

c Institute of Modern Physics, Chinese Academy of Sciences, No. 509 Nanchang Road, Lanzhou 730000, P. R. China

Abstract

A novel rhodamine nitroxide probe was synthesized for monitoring the cellular redox environment based on the reduction of the nitroxide to hydroxylamine. It displayed selective and sensitive response to biological reducing compounds. The different effects of anticancer agent 2-deoxyglucose on the redox environment of normal human liver cells and human hepatoma cells were studied by fluorescence imaging.

Graphical abstract: Visualizing the changes in the cellular redox environment using a novel profluorescent rhodamine nitroxide probe

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Article information

DOI
https://doi.org/10.1039/C3NJ00674C
Article type
Letter
Submitted
22 Jun 2013
Accepted
14 Aug 2013
First published
14 Aug 2013

New J. Chem., 2013,37, 2991-2994

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Visualizing the changes in the cellular redox environment using a novel profluorescent rhodamine nitroxide probe

L. Cao, Q. Wu, Q. Li, S. Shao and Y. Guo, New J. Chem., 2013, 37, 2991 DOI: 10.1039/C3NJ00674C

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