Issue 2, 1995

Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

Abstract

Syntheses of four new pyrimidone analogues of the acetylcholinesterase (AChE) inhibitor huperzine A are reported together with the inhibitory potencies of these compounds for foetal bovine calf serum AChE; β-lactone formation followed by a thermal cycloreversion reaction serves as the key step for introduction of the ethylidene appendage of 12 in the stereochemically correct form.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1995, 283-285

Synthesis and acetylcholinesterase inhibitory activity of several pyrimidone analogues of huperzine A

A. P. Kozikowski, G. Campiani, A. Saxena and B. P. Doctor, J. Chem. Soc., Chem. Commun., 1995, 283 DOI: 10.1039/C39950000283

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements