Homochiral N-protected α-amino glyoxals are readily accessible by oxidation of α-diazoketones derived from natural amino acids and dipeptides using dimethyldioxirane in acetone; the glyoxals can be trapped efficiently in reactions such as Wittig olefination and condensation with amines and vicinal diamines.
P. Darkins, N. McCarthy, M. A. McKervey and T. Ye, J. Chem. Soc., Chem. Commun., 1993, 1222 DOI: 10.1039/C39930001222
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