The methyl ester functionality in arecoline and related esters has been replaced by 1,2,4-oxadiazole to generate the most potent and efficacious muscarinic agonists known.
J. Saunders, A. M. MacLeod, K. Merchant, G. A. Showell, R. J. Snow, L. J. Street and R. Baker, J. Chem. Soc., Chem. Commun., 1988, 1618 DOI: 10.1039/C39880001618
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