Issue 34, 2012
From the journal:

Soft Matter

Mechanically robust PEGDA–MSNs-OH nanocomposite hydrogel with hierarchical meso-macroporous structure for tissue engineering

Shengbing Yang,abc   Jing Wang,*b   Honglue Tan,d   Fanyan Zengb  and  Changsheng Liu*abc  

* Corresponding authors

a East China University of Science and Technology - The State Key Laboratory of Bioreactor Engineering, Shanghai 200237, China

b East China University of Science and Technology - Engineering Research Center for Biomedical Materials of Ministry of Education, Shanghai 200237, China
E-mail: wjbiomat@yahoo.com.cn, csliu@sh163.net
Tel: +86 21 64251358

c East China University of Science and Technology - Key Laboratory for Ultrafine Materials of Ministry of Education, Shanghai 200237, China

d Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine - Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai, China

Abstract

Owing to their tissue-like elasticity, poly(ethylene glycol) (PEG)-based hydrogels are highly desirable as three-dimensional scaffolds for tissue regeneration. Also, their high permeability can mimic the native extracellular matrix. However, their applications are limited by their poor mechanical properties and bioinert nature, which restrict cell adhesion and spreading. This study aims to address both limitations by developing a novel hierarchical nanocomposite hydrogel (NC gel) composed of polyethylene glycol diacrylate (PEGDA) and hydroxyl mesoporous silica nanoparticles (MSNs-OH) via in situ free-radical polymerization. Structural and physicochemical characterization shows that MSNs-OH act as both reinforcing agents and adhesion sites in the hydrogel system, which significantly enhances mechanical properties and cellular affinity. Compared with the unmodified PEG hydrogels, which are fractured easily, MSNs-OH provide the PEG-based NC gels with flexibility due to interactions with PEGDA. Furthermore, the increased protein adsorption capability, the integration of hierarchical macro–mesoporous structure, as well as the introduction of silica, provide a favorable environment for the adhesion and spreading of rat marrow stem cells (RMSCs). These NC hydrogels show promise as scaffolds for tissue engineering.

Graphical abstract: Mechanically robust PEGDA–MSNs-OH nanocomposite hydrogel with hierarchical meso-macroporous structure for tissue engineering

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/C2SM25123J
Article type
Paper
Submitted
17 Jan 2012
Accepted
19 Jun 2012
First published
24 Jul 2012

Soft Matter, 2012,8, 8981-8989

Permissions

Request permissions

Mechanically robust PEGDA–MSNs-OH nanocomposite hydrogel with hierarchical meso-macroporous structure for tissue engineering

S. Yang, J. Wang, H. Tan, F. Zeng and C. Liu, Soft Matter, 2012, 8, 8981 DOI: 10.1039/C2SM25123J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements