Issue 8, 2012
From the journal:

RSC Advances

A one pot synthesis of [1,3,4]-oxadiazoles mediated by molecular iodine†

Srimanta Guin,a   Saroj Kumar Rout,a   Tuhin Ghosh,a   Nilufa Khatuna  and  Bhisma K. Patel*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology, Guwahati, Assam, India
E-mail: patel@iitg.ernet.in
Fax: +91-3612690762

Abstract

A one-pot synthesis of 3-amino-1,3,4-oxadiazoles has been achieved from the corresponding dithiocarbamate salt, employing the thiophilic property of molecular iodine. The precursor thiosemicarbazides could be derived in situ which underwent an intramolecular cyclodesulfurization in the presence of iodine to afford 3-amino-1,3,4-oxadiazoles exclusively. Apart from being milder and environmentally sustainable, this method involves a simple, reliable approach to give good to excellent yields of the desired products and is compatible with a wide range of functional groups.

Graphical abstract: A one pot synthesis of [1,3,4]-oxadiazoles mediated by molecular iodine

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Article information

DOI
https://doi.org/10.1039/C2RA00044J
Article type
Communication
Submitted
06 Jan 2012
Accepted
26 Jan 2012
First published
26 Jan 2012

RSC Adv., 2012,2, 3180-3183

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A one pot synthesis of [1,3,4]-oxadiazoles mediated by molecular iodine

S. Guin, S. K. Rout, T. Ghosh, N. Khatun and B. K. Patel, RSC Adv., 2012, 2, 3180 DOI: 10.1039/C2RA00044J

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