Issue 5, 2012
From the journal:

Green Chemistry

Direct oxidative amidation of aromatic aldehydes using aqueous hydrogen peroxide in continuous flow microreactor systems†

Xiaoying Liua  and  Klavs F. Jensen*a  

* Corresponding authors

a Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
E-mail: kfjensen@mit.edu
Fax: (+1)617-258-8992

Abstract

A practical and economical protocol has been developed for the direct oxidative amidation of aromatic aldehydes with secondary amines to synthesize amides in a single operation under mild conditions within 15–40 min. The utilization of aqueous hydrogen peroxide affords a clean synthetic route. No catalysts or promoting reagents are required.

Graphical abstract: Direct oxidative amidation of aromatic aldehydes using aqueous hydrogen peroxide in continuous flow microreactor systems

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Article information

DOI
https://doi.org/10.1039/C2GC35078E
Article type
Paper
Submitted
16 Jan 2012
Accepted
13 Mar 2012
First published
13 Mar 2012

Green Chem., 2012,14, 1471-1474

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Direct oxidative amidation of aromatic aldehydes using aqueous hydrogen peroxide in continuous flow microreactor systems

X. Liu and K. F. Jensen, Green Chem., 2012, 14, 1471 DOI: 10.1039/C2GC35078E

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