Issue 13, 2011
From the journal:

Soft Matter

PEGylated polyamidoamine dendron-assisted encapsulation of plasmid DNA into in situ forming supramolecular hydrogel†

Junjie Deng,a   Ying Luoa  and  Li-Ming Zhang*a  

* Corresponding authors

a DSAPM Lab and PCFM Lab, Institute of Polymer Science, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou, China
E-mail: ceszhlm@mail.sysu.edu.cn
Fax: +86-20-84112354
Tel: +86-20-84112354

Abstract

For the first time, PEGylated polyamidoamine dendron was used to condense plasmid DNA (pDNA) into the nanoparticles (polyplexes) and subsequently used to interact with α-cyclodextrin in an aqueous system. The resultant pDNA polyplexes could be encapsulated into the in situ forming supramolecuar hydrogel and exhibit sustained release and gene transfection properties.

Graphical abstract: PEGylated polyamidoamine dendron-assisted encapsulation of plasmid DNA into in situ forming supramolecular hydrogel

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Article information

DOI
https://doi.org/10.1039/C1SM05259D
Article type
Communication
Submitted
15 Feb 2011
Accepted
24 May 2011
First published
02 Jun 2011

Soft Matter, 2011,7, 5944-5947

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PEGylated polyamidoamine dendron-assisted encapsulation of plasmid DNA into in situ forming supramolecular hydrogel

J. Deng, Y. Luo and L. Zhang, Soft Matter, 2011, 7, 5944 DOI: 10.1039/C1SM05259D

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