Issue 10, 2011
From the journal:

Soft Matter

Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation†

Igor Y. Perevyazko,ab   Joseph T. Delaney, Jr.,abc   Antje Vollrath,ab   Georges M. Pavlov,abc   Stephanie Schubertabd  and  Ulrich S. Schubert*abc  

* Corresponding authors

a Laboratory of Organic and Macromolecular Chemistry (IOMC), Friedrich-Schiller-University, Humboldtstrasse 10, Jena, Germany
E-mail: ulrich.schubert@uni-jena.de

b Jena Center for Soft Matter (JCSM), Friedrich-Schiller-University, Humboldtstrasse 10, Jena, Germany

c Dutch Polymer Institute (DPI), Post Office Box 902, Eindhoven, The Netherlands

d Laboratory of Pharmaceutical Technology, Friedrich-Schiller-University, Otto-Schott-Strasse 41, Jena, Germany

Abstract

In recent years, the development of polymer nanoparticle suspensions by nanoprecipitation has gained increased attention both by industry and academia. However, the process by which such formulations are prepared is a highly empirically driven enterprise, whereby developing optimized formulations remains an iterative process. In this contribution, a new approach towards exploration of the materials space for these systems is reported, based on systematically varying processing and formulation to understand their influence on the characteristics of the resulting materials. Taking advantage of the tools and techniques that have already been standardized by informatics-driven life sciences disciplines, we have prepared libraries of nanoparticle formulations of poly(methyl methacrylate-stat-acrylate), poly(lactic-co-glycolic acid), and acetal-derivatized dextran by using a pipetting robot. They were subsequently characterized using a dynamic light scattering plate reader, analytical ultracentrifugation, and scanning electron microscopy. With this high-throughput nanoprecipitation approach, large numbers of materials can be prepared, screened, and the formulation rationally optimized.

Graphical abstract: Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation

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Article information

DOI
https://doi.org/10.1039/C1SM05079F
Article type
Paper
Submitted
17 Jan 2011
Accepted
21 Mar 2011
First published
18 Apr 2011

Soft Matter, 2011,7, 5030-5035

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Examination and optimization of the self-assembly of biocompatible, polymeric nanoparticles by high-throughput nanoprecipitation

I. Y. Perevyazko, J. T. Delaney, A. Vollrath, G. M. Pavlov, S. Schubert and U. S. Schubert, Soft Matter, 2011, 7, 5030 DOI: 10.1039/C1SM05079F

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