Issue 2, 2012
From the journal:

New Journal of Chemistry

Dendrimers in nuclear medical imaging†

Cynthia Ghobril,a   Giuseppe Lamanna,a   Marie Kueny-Stotz,a   Antonio Garofalo,a   Claire Billotey*b  and  Delphine Felder-Flesch*a  

* Corresponding authors

a IPCMS UMR CNRS/Université de Strasbourg 7504, 23 rue du Loess BP 43, 67034 Strasbourg Cedex 02, France
E-mail: Delphine.Felder@ipcms.u-strasbg.fr
Fax: +33 (0)3 8810 7246
Tel: +33 (0)3 8810 7163

b LPCML-UCBL UMR 5620 Service de Médecine Nucléaire Pavillon B, 5 place d'Arsonval, 69437 Lyon cedex 03, France
E-mail: Claire.Billotey@univ-lyon1.fr
Fax: +33 (0)4 7211 6957
Tel: +33 (0)4 7268 4617

Abstract

Current progress in the nuclear medicine field has been exploited in the design of tumour-targeting nanoscale carriers being able to deliver radionuclides in a selective manner to improve the outcome of both cancer diagnosis and therapy. In this field dendrimers have a role to play, thanks to their controlled architecture allowing multivalent attachment possibilities of radionuclide chelators and targeting moieties. This perspective highlights the current research focused on discrete dendritic systems as nanoprobes for nuclear medical imaging, both for Single Photon Emission Computed Tomography (SPECT) (99mTc, 111In, 125I) and Positron Emission Tomography (PET) (68Ga). Also a special emphasis is given on radiolabeled (64Cu, 18F, 76Br, 68Ga, 111In) dendrimers targeting αvβ3 integrin as it is a reliable strategy to assess the presence of angiogenesis, one of the most studied and also targeted biological processes.

Graphical abstract: Dendrimers in nuclear medical imaging

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Article information

DOI
https://doi.org/10.1039/C1NJ20416E
Article type
Perspective
Submitted
13 May 2011
Accepted
19 Oct 2011
First published
03 Nov 2011

New J. Chem., 2012,36, 310-323

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Dendrimers in nuclear medical imaging

C. Ghobril, G. Lamanna, M. Kueny-Stotz, A. Garofalo, C. Billotey and D. Felder-Flesch, New J. Chem., 2012, 36, 310 DOI: 10.1039/C1NJ20416E

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