Issue 17, 2010

Liposomes as ‘smart’ pharmaceutical nanocarriers

Abstract

Since the discovery of liposomes, these phospholipid ‘bubbles’ have received enormous attention to be recognized as ‘smart’ pharmaceutical nanocarriers. Recently, much effort has been directed to the development of so-called ‘smart’ stimuli-sensitive liposomes that will respond to certain internal or external stimuli, such as, pH, temperature, redox potential or magnetic field. These programmable delivery systems can also be made ‘multifunctional’ so as to expose certain functions in an orchestrated manner which can be readily modulated by the stimulus. In this article, the evolution of liposomes with emphasis on the recent advances in stimuli-sensitive liposomes has been reviewed.

Graphical abstract: Liposomes as ‘smart’ pharmaceutical nanocarriers

Article information

Article type
Review Article
Submitted
09 Nov 2009
Accepted
11 Mar 2010
First published
12 May 2010

Soft Matter, 2010,6, 4026-4044

Liposomes as ‘smart’ pharmaceutical nanocarriers

R. R. Sawant and V. P. Torchilin, Soft Matter, 2010, 6, 4026 DOI: 10.1039/B923535N

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