Issue 42, 2008
From the journal:

Journal of Materials Chemistry

Magnetic and pH-responsive nanocarriers with multilayer core–shell architecture for anticancer drug delivery

Miao Guo,a   Yu Yan,a   Hongkai Zhang,b   Husheng Yan,*a   Youjia Cao,b   Keliang Liu,c   Shourong Wan,a   Junsheng Huanga  and  Wei Yuea  

* Corresponding authors

a Key Laboratory of Functional Polymer Materials (Nankai University), Ministry of Education, Institute of Polymer Chemistry, Nankai University, Tianjin, P. R. China

b Key Laboratory of Bioactive Materials (Nankai University), Ministry of Education, College of Life Sciences, Nankai University, Tianjin, P. R. China

c Beijing Institute of Pharmacology and Toxicology, Beijing, P. R. China

Abstract

A multifunctional nanocarrier with multilayer core–shell architecture was prepared by alkaline coprecipitation of ferric and ferrous ions in the presence of a triblock copolymer, methoxy poly(ethylene glycol)-block-poly(methacrylic acid)-block-poly(glycerol monomethacrylate) (denoted MPEG-b-PMAA-b-PGMA), in aqueous solution. The core of the nanocarrier is a superparamagnetic Fe3O4 nanoparticle, on which the PGMA block of the triblock copolymer is attached. The PMAA block forms the inner shell and the MPEG block forms the outermost shell. The anticancer agent adriamycin (ADR), as a model drug with an amine group and a hydrophobic moiety, was loaded into the nanocarrier at pH 7.4 by combined action of ionic bonding and hydrophobic interaction. The hydrophobic main chain of PMAA and the hydrophobic microenvironment created by MPEG contribute to the hydrophobic interaction. The synergistic effect between the ionic bond and the hydrophobic interaction significantly enhances the loading capacity. At endosomal/lysosomal acidic pH (<5.5), protonation of polycarboxylate anions of PMAA (pKa = 5.6) breaks the ionic bond between the carrier and ADR, leading to the release of ADR because the hydrophobic interaction alone is very weak due to the relatively hydrophilic character of the nanocarrier.

Graphical abstract: Magnetic and pH-responsive nanocarriers with multilayer core–shell architecture for anticancer drug delivery

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Article information

DOI
https://doi.org/10.1039/B810061F
Article type
Paper
Submitted
13 Jun 2008
Accepted
06 Aug 2008
First published
29 Sep 2008

J. Mater. Chem., 2008,18, 5104-5112

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Magnetic and pH-responsive nanocarriers with multilayer core–shell architecture for anticancer drug delivery

M. Guo, Y. Yan, H. Zhang, H. Yan, Y. Cao, K. Liu, S. Wan, J. Huang and W. Yue, J. Mater. Chem., 2008, 18, 5104 DOI: 10.1039/B810061F

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