Issue 23, 2007
From the journal:

Chemical Communications

A triazole-templated ring-closing metathesis for constructing novel fused and bridged triazoles†

Xuejun Zhang,a   Richard P. Hsung*a  and  Hongyan Lia  

* Corresponding authors

a Division of Pharmaceutical Sciences and Department of Chemistry, 777 Highland Avenue, University of Wisconsin, Madison, WI, USA
E-mail: rhsung@wisc.edu
Fax: (+1) 608-262-5345
Tel: (+1) 608-890-1069

Abstract

The feasibility of trapping the vinyl copper intermediate generated in situ from azide-[3 + 2] cycloadditions and viability of employing these triazoles as unique templates for ring-closing metathesis are described here; this work effectively combines the two powerful reactions for the first time to construct various de novo fused and bridged triazoles that are otherwise not trivial to synthesize.

Graphical abstract: A triazole-templated ring-closing metathesis for constructing novel fused and bridged triazoles

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Article information

DOI
https://doi.org/10.1039/B701040K
Article type
Communication
Submitted
23 Jan 2007
Accepted
27 Feb 2007
First published
13 Mar 2007

Chem. Commun., 2007, 2420-2422

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A triazole-templated ring-closing metathesis for constructing novel fused and bridged triazoles

X. Zhang, R. P. Hsung and H. Li, Chem. Commun., 2007, 2420 DOI: 10.1039/B701040K

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