Issue 4, 2007
From the journal:

Natural Product Reports

Synthesis of macrocyclic shellfish toxins containing spiroimine moieties

Patrick D. O'Connora  and  Margaret A. Brimble*a  

* Corresponding authors

a Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand
E-mail: m.brimble@auckland.ac.nz
Tel: +64 9 3737599

Abstract

Covering: 1993–2006

An overview of the structure and biological activity of macrocyclic polyketides derived from dinoflagellates that contain unusual cyclic imine units is provided. The total and partial syntheses of these molecules are discussed with an emphasis on the construction of the spiroimine functionality thought to be the key pharmacophore of these fast-acting shellfish toxins.

Graphical abstract: Synthesis of macrocyclic shellfish toxins containing spiroimine moieties

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Article information

DOI
https://doi.org/10.1039/B700307M
Article type
Review Article
Submitted
08 Jan 2007
First published
02 Apr 2007

Nat. Prod. Rep., 2007,24, 869-885

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Synthesis of macrocyclic shellfish toxins containing spiroimine moieties

P. D. O'Connor and M. A. Brimble, Nat. Prod. Rep., 2007, 24, 869 DOI: 10.1039/B700307M

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