Issue 4, 2007
From the journal:

Green Chemistry

A HCN-based reaction under microreactor conditions: industrially feasible and continuous synthesis of 3,4-diamino-1H-isochromen-1-ones

Davy R. J. Ackea  and  Christian V. Stevens*a  

* Corresponding authors

a Research Group SynBioC, Department of Organic Chemistry, Faculty of Bioscience Engineering, Ghent University, Coupure links 653, B-9000 Ghent, Belgium
E-mail: Chris.Stevens@UGent.be
Fax: +32 9264 6243
Tel: +32 9264 5950

Abstract

Microreactor technology has been studied as a suitable process to produce chemicals via multicomponent reactions. In this study, efforts were made to produce 3,4-diamino-1H-isochromen-1-ones. Based on a known reaction procedure, using in situ generated HCN, a safe reaction setup was created to avoid the release of the hazardous gas during the process. The 3,4-diamino-1H-isochromen-1-ones were produced continuously in moderate to good yields.

Graphical abstract: A HCN-based reaction under microreactor conditions: industrially feasible and continuous synthesis of 3,4-diamino-1H-isochromen-1-ones

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Article information

DOI
https://doi.org/10.1039/B615186H
Article type
Paper
Submitted
18 Oct 2006
Accepted
12 Jan 2007
First published
26 Jan 2007

Green Chem., 2007,9, 386-390

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A HCN-based reaction under microreactor conditions: industrially feasible and continuous synthesis of 3,4-diamino-1H-isochromen-1-ones

D. R. J. Acke and C. V. Stevens, Green Chem., 2007, 9, 386 DOI: 10.1039/B615186H

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