Issue 18, 2006
From the journal:

Organic & Biomolecular Chemistry

Discovery of aspoquinolones A–D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining†

Kirstin Scherlacha  and  Christian Hertweck*a  

* Corresponding authors

a Leibniz-Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11 a, and Friedrich-Schiller-University, Jena, Germany, Germany
E-mail: Christian.Hertweck@hki-jena.de
Fax: + 49 3641 656705
Tel: + 49 3641 656700

Abstract

Motivated by the observation that the Aspergillus nidulans genome bears multiple anthranilic acid synthase gene copies, the fungal metabolome was reinvestigated under various fermentation conditions, resulting in the discovery of novel prenylated quinolin-2-one alkaloids, two of which bear unprecedented terpenoid side chains.

Graphical abstract: Discovery of aspoquinolones A–D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining

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Article information

DOI
https://doi.org/10.1039/B607011F
Article type
Paper
Submitted
17 May 2006
Accepted
17 Jul 2006
First published
10 Aug 2006

Org. Biomol. Chem., 2006,4, 3517-3520

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Discovery of aspoquinolones A–D, prenylated quinoline-2-one alkaloids from Aspergillus nidulans, motivated by genome mining

K. Scherlach and C. Hertweck, Org. Biomol. Chem., 2006, 4, 3517 DOI: 10.1039/B607011F

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