Issue 7, 2006
From the journal:

Organic & Biomolecular Chemistry

Electrostatic interactions in cations and their importance in biology and chemistry

Deborah M. Smitha  and  K. A. Woerpel*a  

* Corresponding authors

a Department of Chemistry, University of California, Irvine, California, USA
E-mail: kwoerpel@uci.edu
Fax: 949.834.2290
Tel: 949.824.4239

Abstract

Electrostatic effects exert strongly stabilizing influences on cations, in many cases controlling the conformational preferences of these cations. The lowest energy conformers are ones where the positive charge is brought closest to substituents bearing partial negative charges. These conformational biases, along with stereoelectronic effects, can control the stereoselectivity of reactions involving carbocationic intermediates.

Graphical abstract: Electrostatic interactions in cations and their importance in biology and chemistry

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Article information

DOI
https://doi.org/10.1039/B600056H
Article type
Perspective
Submitted
03 Jan 2006
Accepted
26 Jan 2006
First published
27 Feb 2006

Org. Biomol. Chem., 2006,4, 1195-1201

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Electrostatic interactions in cations and their importance in biology and chemistry

D. M. Smith and K. A. Woerpel, Org. Biomol. Chem., 2006, 4, 1195 DOI: 10.1039/B600056H

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