Issue 10, 2006
From the journal:

Chemical Communications

Unusual entry to the novel 8-halo-N1-ribosyl hypoxanthine system by degradation of a cyclic adenosine-5′-diphosphate ribose analogue

Christelle Moreau,a   Timothy J. Woodmana  and  Barry V. L. Potter*a  

* Corresponding authors

a Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, UK
E-mail: b.v.l.potter@bath.ac.uk
Fax: +44-1225-386114
Tel: +44-1225-386639

Abstract

Cyclic 8-bromo-inosine-5′-diphosphate ribose (8-Br-N1-cIDPR) was cleanly degraded at acidic pH by N9 ribosyl scission and subsequent pyrophosphate cleavage to give 8-bromo-N1-ribosyl hypoxanthine 5′-monophosphate (8-Br-N1-IMP), a novel class of mononucleotide, as the sole product.

Graphical abstract: Unusual entry to the novel 8-halo-N1-ribosyl hypoxanthine system by degradation of a cyclic adenosine-5′-diphosphate ribose analogue

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Article information

DOI
https://doi.org/10.1039/B517916E
Article type
Communication
Submitted
16 Dec 2005
Accepted
11 Jan 2006
First published
25 Jan 2006

Chem. Commun., 2006, 1127-1129

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Unusual entry to the novel 8-halo-N1-ribosyl hypoxanthine system by degradation of a cyclic adenosine-5′-diphosphate ribose analogue

C. Moreau, T. J. Woodman and B. V. L. Potter, Chem. Commun., 2006, 1127 DOI: 10.1039/B517916E

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