Issue 5, 2006
From the journal:

Chemical Communications

Rapid formation of amidesvia carbonylative coupling reactions using a microfluidic device

Philip W. Miller,a   Nicholas J. Long,a   Andrew J. de Mello,a   Ramon Vilar,b   Jan Passchierc  and  Antony Geec  

a Department of Chemistry, Imperial College London, London, UK
E-mail: n.long@imperial.ac.uk
Fax: +44 (0)20 75945804
Tel: +44 (0)20 75945781

b Institute of Chemical Research of Catalonia (ICIQ), Avgda. Paisos Catalans 16, 43007 Tarragona, Spain
E-mail: rvilar@iciq.es
Fax: +34 977 920 228
Tel: +34 977 920 212

c PET Imaging Division, Translational Medicine and Genetics, GlaxoSmithKline, Academic Centre for Clinical Investigation, Addenbrooke's Hospital, Hills Road, Cambridge, UK

Abstract

Carbonylative cross-coupling reactions of arylhalides to form secondary amides were rapidly carried out on a glass-fabricated microchip—the first time a microstructured device has been used to perform a gas–liquid carbonylation reaction.

Graphical abstract: Rapid formation of amides via carbonylative coupling reactions using a microfluidic device

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Article information

DOI
https://doi.org/10.1039/B515710B
Article type
Communication
Submitted
08 Nov 2005
Accepted
21 Nov 2005
First published
15 Dec 2005

Chem. Commun., 2006, 546-548

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Rapid formation of amides via carbonylative coupling reactions using a microfluidic device

P. W. Miller, N. J. Long, A. J. de Mello, R. Vilar, J. Passchier and A. Gee, Chem. Commun., 2006, 546 DOI: 10.1039/B515710B

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