Issue 1, 2007
From the journal:

Chemical Society Reviews

Ring closing enyne metathesis: A powerful tool for the synthesis of heterocycles

Hélène Villar,ab   Marcus Fringsa  and  Carsten Bolm*a  

* Corresponding authors

a Institut für Organische Chemie der RWTH Aachen, Landoltweg 1, 52074 Aachen, Germany
E-mail: Carsten.Bolm@oc.rwth-aachen.de

b New address: Equipe Matériaux Tensioactifs, BP 239, Polymères et Colloïdaux, UMR 7565 CNRS-UHP, Université Henri Poincaré Nancy I, France

Abstract

The ring closing metathesis (RCM) is a powerful method in organic synthesis for the preparation of cyclic compounds by formation of new carbon–carbon bonds. In the past years a particular subclass of the RCM, the ring closing enyne metathesis (RCEYM), has attracted attention due to its synthetic potential in the generation of ring structures with 1,3-diene moieties, which can subsequently be further functionalised. In this tutorial review mechanistic considerations will be described and the synthetic power of this useful and attractive carbon–carbon bond forming reaction will be illustrated by recent examples of RCEYM applications in the preparation of heterocyclic compounds.

Graphical abstract: Ring closing enyne metathesis: A powerful tool for the synthesis of heterocycles

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Article information

DOI
https://doi.org/10.1039/B508899M
Article type
Tutorial Review
Submitted
02 Aug 2006
First published
04 Oct 2006

Chem. Soc. Rev., 2007,36, 55-66

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Ring closing enyne metathesis: A powerful tool for the synthesis of heterocycles

H. Villar, M. Frings and C. Bolm, Chem. Soc. Rev., 2007, 36, 55 DOI: 10.1039/B508899M

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