Issue 9, 2005
From the journal:

Chemical Communications

PS-IIDQ: an efficient polymer-supported amide coupling reagent

Eric Valeura  and  Mark Bradley*a  

* Corresponding authors

a Combinatorial Centre of Excellence, School of Chemistry, University of Southampton, Southampton, UK
E-mail: mb14@soton.ac.uk

Abstract

Polystyrene-IIDQ is a polymer-supported coupling reagent that couples carboxylic acids to amines in good yields and high purity without the requirement of a pre-activation step. Importantly the order of addition of the amine, acid or coupling agent makes no difference to the efficiency of the coupling reaction and the reagent can be readily regenerated.

Graphical abstract: PS-IIDQ: an efficient polymer-supported amide coupling reagent

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Article information

DOI
https://doi.org/10.1039/B414889D
Article type
Communication
Submitted
27 Sep 2004
Accepted
19 Nov 2004
First published
17 Jan 2005

Chem. Commun., 2005, 1164-1166

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PS-IIDQ: an efficient polymer-supported amide coupling reagent

E. Valeur and M. Bradley, Chem. Commun., 2005, 1164 DOI: 10.1039/B414889D

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