Issue 1, 2001

Microchip-based synthesis and analysis: Control of multicomponent reaction products and intermediates

Abstract

A miniaturised-SYNthesis and Total Analysis System (μSYNTAS) was used for the solution-phase synthesis and on-line analysis (TOF-MS) of Ugi multicomponent reaction (MCR) products. This approach provides an unusually high degree of control of the MCR and delivers detailed, novel information on reaction intermediates in real-time. Specifically, the Ugi 4 component condensation (4CC) involving the reaction of an amine, acid, aldehyde and isocyanide species was performed at room temperature in a controllable fashion. Furthermore, observation of the nitrilium intermediate, cyclohexyl(2-piperidin-1-ylethylidyne)ammonium chloride, is presented for the first time.

Article information

Article type
Paper
Submitted
12 Sep 2000
Accepted
13 Nov 2000
First published
18 Dec 2000

Analyst, 2001,126, 24-27

Microchip-based synthesis and analysis: Control of multicomponent reaction products and intermediates

M. C. Mitchell, V. Spikmans and A. J. D. Mello, Analyst, 2001, 126, 24 DOI: 10.1039/B007397K

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