Issue 24, 2000
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

(Fluoren-9-ylmethoxy)carbonyl (Fmoc) amino acidazides: Synthesis, isolation, characterisation, stability and application to synthesis of peptides

Vommina V. Suresh Babu,*a   Kuppanna Anandaa  and  Ganga-Ramu Vasanthakumara  

* Corresponding authors

a Department of Studies in Chemistry, Bangalore University, Central College Campus, Bangalore, India

Abstract

The synthesis of Fmoc amino acid azides starting from the corresponding protected amino acid and sodium azide (NaN3) by the mixed anhydride method using isobutoxycarbonyl chloride (IBC-Cl) or by the acid chloride method is described. Isolated as crystalline solids, they are stable at room temperature, with a long shelf-life, as well as in aqueous washing operations. They are useful as coupling agents in peptide synthesis.

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Article information

DOI
https://doi.org/10.1039/B006756N
Article type
Paper
Submitted
17 Aug 2000
Accepted
19 Oct 2000
First published
05 Dec 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 4328-4331

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(Fluoren-9-ylmethoxy)carbonyl (Fmoc) amino acid azides: Synthesis, isolation, characterisation, stability and application to synthesis of peptides

V. V. S. Babu, K. Ananda and G. Vasanthakumar, J. Chem. Soc., Perkin Trans. 1, 2000, 4328 DOI: 10.1039/B006756N

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