SCHEDULED MAINTENANCE
(5S
)-(5-tert-Butyldimethylsiloxymethyl)furan-2(5H)-one has been converted into cytosine 2′,3′-dideoxy-3′,5′-homocyclic monophosphate (and its 5-fluoro congener) together with an adenosine homocyclic monophosphate. These were designed as inhibitors of HIV reverse transcriptase although they did not possess such activity.
M. G. B. Drew, S. Gorsuch, J. H. M. Gould and J. Mann, J. Chem. Soc., Perkin Trans. 1, 1999, 969 DOI: 10.1039/A900800D
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