The three component condensation reaction of ethyl trifluoroacetate, hydrazine and amidines in the presence of sodium hydroxide in tetrahydrofuran at reflux temperature gave the corresponding 3-trifluoromethyl-5-substituted 1,2,4-triazoles in good to excellent yields.
K. Funabiki, N. Noma, G. Kuzuya, M. Matsui and K. Shibata, J. Chem. Res. (S), 1999, 300 DOI: 10.1039/A900520J
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