SCHEDULED MAINTENANCE
The reaction of 2-aminopyrazine 1 with the glyoxal derivatives 2a–c gave the bicyclic imidazolopyrazinones 3a,b and the monocyclic N-substituted aminopyrazines 4b and 5c. Compounds 3 feature unique crystallographic characteristics. Their reactivity towards superoxide anion is about five times the reactivity of Trolox®, while the monocyclic pyrazines are inactive.
I. Devillers, B. de Wergifosse, M. Bruneau, B. Tinant, J. Declercq, R. Touillaux, J. Rees and J. Marchand-Brynaert, J. Chem. Soc., Perkin Trans. 2, 1999, 1481 DOI: 10.1039/A900289H
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