Issue 10, 1999
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Condensation of thiourea derivatives with carbonyl compounds: one-pot synthesis of N-alkyl-1,3-thiazol-2-amines and of 3-alkyl-1,3-thiazolimines

Carla Boga,   Luciano Forlani,   Cristian Silvestroni,   Anna Bonamartini Corradi  and  Paolo Sgarabotto  

Abstract

The reactions of ketones and N-substituted thioureas, in the presence of HCl (or HBr) and DMSO afford mixtures of the title compounds which are easily separated on a silica gel column. This method avoids the classical use of α-haloketones. The mechanism of these reactions involves the enolization of ketones and the activation of thiourea sulfur, probably by oxygen transfer from DMSO.

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Article information

DOI
https://doi.org/10.1039/A809086F
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1999, 1363-1368

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Condensation of thiourea derivatives with carbonyl compounds: one-pot synthesis of N-alkyl-1,3-thiazol-2-amines and of 3-alkyl-1,3-thiazolimines

C. Boga, L. Forlani, C. Silvestroni, A. Bonamartini Corradi and P. Sgarabotto, J. Chem. Soc., Perkin Trans. 1, 1999, 1363 DOI: 10.1039/A809086F

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