Issue 17, 1998
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Migration of an acyl group in the pyrazole system: synthesis of 1-acyl-3-hydroxy-1H-pyrazoles and related derivatives. A new preparation of N,N ′-diacylhydrazines

Vladimir Kepe,   Franc Požgan,   Amalija Golobič,   Slovenko Polanc  and  Marijan Kočevar  

Abstract

A new general method for the synthesis of 1-acyl-3-hydroxy-1H-pyrazoles 5a–f and related derivatives 5g–i starting from 4-ethoxymethylene-2-phenyloxazol-5(4H )-one (1) and hydrazides, 4-phenylsemicarbazide, 4-phenylthiosemicarbazide and benzyl carbazate in boiling dioxane is described. The method includes a migration of an acyl or related unit. The X-ray study and NMR spectroscopic examination confirmed the structure of the products. A one-pot synthesis of N,N ′-diacylhydrazines from hydrazides by the assistance of oxazolone 1 is also presented.

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Article information

DOI
https://doi.org/10.1039/A803973I
Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1998, 2813-2816

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Migration of an acyl group in the pyrazole system: synthesis of 1-acyl-3-hydroxy-1H-pyrazoles and related derivatives. A new preparation of N,N ′-diacylhydrazines

V. Kepe, F. Požgan, A. Golobič, S. Polanc and M. Kočevar, J. Chem. Soc., Perkin Trans. 1, 1998, 2813 DOI: 10.1039/A803973I

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