Issue 22, 1997

Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

Abstract

The crystal structure of an amine phenol complex of gallium(III), [{1,12-bis(2-hydroxy-3-methoxybenzyl)-1,5,8,12-tetraazadodecane}gallium(III)] [Ga(madd)]+, a potent new antimalarial which selectively targets chloroquine-resistant organisms is reported; the compound is shown to directly inhibit heme polymerization.

Article information

Article type
Paper

Chem. Commun., 1997, 2223-2224

Structure of a novel antimalarial gallium(III) complex with selective activity against chloroquine-resistant Plasmodium falciparum

V. Sharma, D. Piwnica-Worms, V. Sharma, A. Beatty and D. E. Goldberg, Chem. Commun., 1997, 2223 DOI: 10.1039/A705563C

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